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Trovati 124 risultati per "medicina" (Pagina 7 di 11) 1214.3ms • aggiornato
inaugurato il presidio integrato Santa Caterina della Rosa

inaugurato il presidio integrato Santa Caterina della Rosa

A pieno regime da febbraio eroga prestazioni di guardia medica 24ore su 24, diagnostica, unità di fisiokinesiterapia, ambulatori specialistici e due sale operatorie per la chirurgia ambulatoriale.

Claudio_di_Salvo Health 29 Jan 2009
173.7K 0
Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Resp

Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Resp

Silencing of Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Responsive Cancer Cells.Sabrina Rotolo 1, Simona Ceccarelli 1, Ferdinando Romano 1, Luigi Frati 1,2, Cinzia Marchese 1, Antonio Angeloni 1* 1 Dipartimento di Medicina Sperimentale, Universita` Sapienza di Roma, Roma, Italy, 2 Istituto Neurologico Mediterraneo ‘‘Neuromed, Pozzilli, ItalyAbstract : BackgroundKeratinocyte growth factor receptor (KGFR) is a splice variant of the FGFR2 gene expressed in epithelial cells. Activation of KGFR is a key factor in the regulation of physiological processes in epithelial cells such as proliferation, differentiation and wound healing. Alterations of KGFR signaling have been linked to the pathogenesis of different epithelial tumors. It has been also hypothesized that its specific ligand, KGF, might contribute to the development of resistance to 5-fluorouracil (5-FU) in epithelial cancers and tamoxifen in estrogen-positive breast cancers.Abstract : Methodology/Principal FindingsSmall interfering RNA was transfected into a human keratinocyte cell line (HaCaT), a breast cancer derived cell line (MCF-7) and a keratinocyte primary culture (KCs) to induce selective downregulation of KGFR expression. A strong and highly specific reduction of KGFR expression was observed at both RNA (reduction = 75.7%, P = 0.009) and protein level. KGFR silenced cells showed a reduced responsiveness to KGF treatment as assessed by measuring proliferation rate (14.2% versus 39.0% of the control cells, P

Redazione Health 03 Jul 2008
180.1K 0
Accordo quadro fra Cnr e Ospedale Pediatrico Bambino Gesù

Accordo quadro fra Cnr e Ospedale Pediatrico Bambino Gesù

L’obiettivo: sviluppare programmi di ricerca comuni nelle scienze della vita, tecnologie biomediche e medicina. Ma anche far parte di un più ampio processo che miri all’efficacia ed efficienza del sistema salute italiano.

CNR Health 13 Mar 2008
163.9K 0
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